ea0066oc4.3 | Oral Communications 4 | BSPED2019
Mancini Alessandra
, Howard Sasha R
, Cabrera Claudia P
, Barnes Michael R
, David Alessia
, Wehkalampi Karoliina
, Vassert Gilbert
, Cariboni Anna
, Garcia Maria Isabelle
, Guasti Leonardo
, Dunkel Leo
Background: The initiation of puberty is heralded by increasing gonadotropin-releasing hormone (GnRH) secretion from the hypothalamus. During embryonic life the GnRH neuroendocrine network develops thanks to a coordinated migration of neurons from the nasal placode to the forebrain. Our group has previously demonstrated that dysregulation in GnRH neuronal migration leads to delayed pubertal onset. Late puberty affects up to 2% of the population and is associated with adverse h...